Frontiers in Immunology (2025). NK cell-related genes-driven novel molecular subtyping and prognostic signatures for Wilms tumor.
: Characterized by a classic triphasic pattern containing blastemal, epithelial, and stromal cells.
The cure rate is excellent, but survivors require lifelong monitoring for: Monitoring for chronic kidney disease. Cardiotoxicity: If Doxorubicin or chest radiation was used. Frontiers in Immunology (2025)
| | Definition | Key Feature | | :--- | :--- | :--- | | I | Tumor limited to kidney, completely resected with intact capsule | No rupture; negative lymph nodes | | II | Tumor extends beyond kidney but completely resected | Involves renal sinus, vessels, or peri-renal soft tissue | | III | Residual non-hematogenous tumor confined to abdomen | Positive lymph nodes, spillage, incomplete margins | | IV | Hematogenous metastases (most commonly to lungs or liver) | Pulmonary nodules | | V | Synchronous bilateral renal tumors at diagnosis | Involves both kidneys |
Wilms tumor, also known as Nephroblastoma , is the most common malignant kidney tumor in children, typically diagnosed between ages 3 and 5. It accounts for approximately 6%–7% of all childhood cancers. Slideshare Key Epidemiological Facts Prevalence
: Most commonly diagnosed between 2 and 3 years of age.
Wilms tumor was first described by German pathologist Max Wilms in 1899. It is a relatively rare disease, accounting for about 1% of all childhood cancers. However, it is the most common type of kidney cancer in children, and its incidence is highest in children under the age of 5 years.
The clinical presentation often follows a predictable pattern: Wilms Tumor - StatPearls - NCBI Bookshelf - NIH
Radiation to the lungs can lead to subclinical restrictive lung disease or fibrosis. Slide-by-Slide PPT Presentation Outline The cure rate is excellent, but survivors require
Identifying epigenetic changes helps in screening children with overgrowth syndromes.